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KMID : 0604520130390020089
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Journal of the Society of Cosmetic Scientists of Korea
2013 Volume.39 No. 2 p.89 ~ p.96
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Preparation and Evaluation of Polymer Microspheres Containing Broussonetia Kazinoki Root Extract
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Lim Hyung-Jun
Lee Jin-Young
Kim Han-Byul
Kim Do-Hoon
Shin Song-Seok
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Abstract
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This study demonstrate that polymeric microspheres composed of poly (ethylene adipate) (PEA) and poly (methyl methacrylate) (PMMA) can encapsulate and remarkably stabilize Broussonetia kazinoki root extract. We compared the long-term stability and the activity of Broussonetia kazinoki root extract in polymeric microspheres fabricated with different polymer ratio of PEA and PMMA. PMMA was incorporated to the PEA microsphere in order to reinforce the physical strength of microsphere, and there was no noticeable negative effect on the activity of Broussonetia kazinoki root extract. Optical microscope (OM), polarized microscope (PM), and scanning electron microscope (SEM) results showed that PMMA incorporated microspheres were very spherical and had smoothsurface. On the other hand, PEA microspheres showed relatively irregular morphology due to the low physical strength of microspheres. Moreover, the mushroom tyrosinase activities were measured for testing the inhibitory activity of Broussonetia kazinoki root extract encapsulated in polymeric microspheres, and these microspheres showed the effective suppression of mushroom tyrosinase activity. Consequently, polymeric microspheres produced in this study may be beneficial for the research of improving stability and protecting labile substances incorporated into the polymeric microspheres.
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KEYWORD
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Broussonetia kazinoki root extract, microsphere, encapsulation, kazinol C, whitening
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